Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry.

@article{Maskey2004AnticancerAA,
  title={Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry.},
  author={Rajendra Prasad Maskey and Elisabeth Helmke and Oliver Kayser and Heinz Herbert Fiebig and Armin Maier and Andreas Busche and Hartmut Laatsch},
  journal={The Journal of antibiotics},
  year={2004},
  volume={57 12},
  pages={771-9}
}
The ethyl acetate extract from the Streptomyces sp. isolate B8652 delivered the trioxacarcins A to approximately C (2a to approximately 2c) and additionally three new derivatives designated as trioxacarcins D to approximately F (2d to approximately 2f). All trioxacarcins showed high anti-bacterial and some of them high anti-tumor and anti-malaria activity. The structures of the new antibiotics were derived from mass, 1D and 2D NMR spectra and confirmed by comparison of the NMR data with those… CONTINUE READING