Anti-cancer activity and mechanistic features of a NK cell activating molecule

Abstract

Natural cytotoxicity receptors (NCRs) are major activating receptors involved in NK cytotoxicity. NCR expression varies with the activation state of NK cells, and the expression level correlates with NK cells’ natural cytotoxicity. In this study, we found that Gö6983, a PKC inhibitor, induced a remarkable increase of NCR expression on primary NK cells, but… (More)
DOI: 10.1007/s00262-009-0680-0

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