Anti-biofilm effect of novel thiazole acid analogs against Pseudomonas aeruginosa through IQS pathways.

@article{Li2018AntibiofilmEO,
  title={Anti-biofilm effect of novel thiazole acid analogs against Pseudomonas aeruginosa through IQS pathways.},
  author={Shengrong Li and Siyu Chen and Jilin Fan and Zhen Cao and Weihao Ouyang and Ning Tong and Xin Hu and Jie Hu and Peishan Li and Zifeng Feng and Xi Huang and Yuying Li and Mingshan Xie and Ruikun He and Jingyi Jian and Biyuan Wu and Chen Xu and Weijian Wu and JiaLiang Guo and Jing Lin and Pinghua Sun},
  journal={European journal of medicinal chemistry},
  year={2018},
  volume={145},
  pages={64-73}
}
IQS has been proven to be a new quorum sensing (QS) system against bacterial biofilm formation, which is activated in the common phosphate-limiting environment of infected tissues taking over the central las system. Up to now, numerous biofilm inhibitors which function by affecting traditional QS system have been reported. However, no compound has been… CONTINUE READING