Anti-aversive effects of the atypical antipsychotic, aripiprazole, in animal models of anxiety.

@article{Biojone2011AntiaversiveEO,
  title={Anti-aversive effects of the atypical antipsychotic, aripiprazole, in animal models of anxiety.},
  author={Caroline Biojone and P C Casarotto and Leonardo L B M Resstel and H. H{\'e}lio Zangrossi and Francisco S Guimar{\~a}es and Fabricio A Moreira},
  journal={Journal of psychopharmacology},
  year={2011},
  volume={25 6},
  pages={801-7}
}
Aripiprazole is a unique antipsychotic that seems to act as a partial agonist at dopamine D2-receptors, contrasting with other drugs in this class, which are silent antagonists. Aripiprazole may also bind to serotonin receptors. Both neurotransmitters may play major roles in aversion-, anxiety- and panic-related behaviours. Thus, the present work tested the hypothesis that this antipsychotic could also have anti-aversive properties. Male Wistar rats received injections of aripiprazole (0.1-10… CONTINUE READING

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