Anti-atherosclerotic activity of the calcium antagonist lacidipine in cholesterol-fed hamsters.

@article{Cristofori2000AntiatheroscleroticAO,
  title={Anti-atherosclerotic activity of the calcium antagonist lacidipine in cholesterol-fed hamsters.},
  author={P. Cristofori and A. Lanzoni and G. Gaviraghi and J. Turton and A. Sbarbati},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2000},
  volume={54 2},
  pages={
          93-9
        }
}
We have investigated the activity of the calcium antagonist lacidipine in male hamsters fed an atherogenic diet containing 2% cholesterol and 5% butter. Animals were examined at 14, 20 and 24 weeks of treatment. At 14 weeks, in hamsters fed the atherogenic diet and without lacidipine treatment, there were significant increases in serum levels of total cholesterol, triglycerides and lipoproteins; these values were approximately similar at week 24. Lacidipine treatment at 0.3, 1.0 and 3.0 mg/kg/d… Expand
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References

SHOWING 1-10 OF 11 REFERENCES
Calcium antagonists suppress atherogenesis in aorta but not in the intramural coronary arteries of cholesterol-fed rabbits.
Lacidipine: Prevention of Vascular Damage Induced by Hypertension
Pharmacology of Lacidipine, a Vascular‐Selective Calcium Antagonist
Clinical Pharmacology of Lacidipine
...
1
2
...