Anti-asthma drugs and capsaicine-induced microvascular effects in lower airways

  title={Anti-asthma drugs and capsaicine-induced microvascular effects in lower airways},
  author={I. Erjef{\"a}lt and C. Persson},
  journal={Agents and Actions},
  • I. Erjefält, C. Persson
  • Published 2005
  • Medicine
  • Agents and Actions
  • Substance P, capsaicine and bicervical vagal stimulation may increase microvascular permeability to macromolecules in lower airways. In previous studies techniques were employed that could have adversely affected the microvasculature. An atraumatic method of exposing the guinea-pig trachea to constant concentrations of drugs followed by quantitation of the blood-pool (in vivo99Tcm-labelled erythrocytes) and extravasated macromolecules (Fitc.-dextran) has now been developed. Capsaicine produced… CONTINUE READING
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