Anti-asthma drugs and capsaicine-induced microvascular effects in lower airways

@article{Erjeflt2005AntiasthmaDA,
  title={Anti-asthma drugs and capsaicine-induced microvascular effects in lower airways},
  author={I. Erjef{\"a}lt and C. Persson},
  journal={Agents and Actions},
  year={2005},
  volume={16},
  pages={9-10}
}
  • I. Erjefält, C. Persson
  • Published 2005
  • Medicine
  • Agents and Actions
  • Substance P, capsaicine and bicervical vagal stimulation may increase microvascular permeability to macromolecules in lower airways. In previous studies techniques were employed that could have adversely affected the microvasculature. An atraumatic method of exposing the guinea-pig trachea to constant concentrations of drugs followed by quantitation of the blood-pool (in vivo99Tcm-labelled erythrocytes) and extravasated macromolecules (Fitc.-dextran) has now been developed. Capsaicine produced… CONTINUE READING
    2 Citations
    Anti‐inflammatory properties of local anesthetics and their present and potential clinical implications
    • 282
    TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo
    • 22

    References

    SHOWING 1-9 OF 9 REFERENCES
    A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig.
    • 415
    • PDF
    E
    • 125,435
    • PDF
    Capsaicin-sensitive vagal neurons involved in control of vascular permeability in rat trachea.
    • 188
    Distribution and constrictor effect of substance P in guinea - pig tracheo bronchial tissue
    • Mechanisms of Lung Microvascular Injury , Ann . N . Y . Acad . Sci .
    • 1977
    SALDEEN, Framkallande av lungddem reed substanser med kort halveringstid i blod
    • Acta Soc. Med. Suecanae Hygiea,
    • 1981