Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells.

@article{Kinoshita2010Antiaquaporin4AI,
  title={Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells.},
  author={Makoto Kinoshita and Yuji Nakatsuji and Takashi Kimura and Masayuki Moriya and Kazushiro Takata and Tatsusada Okuno and Atsushi Kumanogoh and Koji Kajiyama and Hiroo Yoshikawa and Saburo Sakoda},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={394 1},
  pages={205-10}
}
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system (CNS). Anti-aquaporin-4 antibody (AQP4-Ab) is a highly specific serum autoantibody that is detected in patients with NMO. Several lines of evidence indicate that AQP4-Ab not only serves as a disease marker but also plays a pivotal role in the pathogenesis of NMO. Although the pathogenicity of AQP4-Ab in vivo has recently been demonstrated, the presence of CNS antigen-specific T cells is recognized… CONTINUE READING

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