Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA).

@article{Dremina2004AntiapoptoticPB,
  title={Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA).},
  author={Elena S Dremina and Victor S. Sharov and Keshava Kumar and A. G. Zaidi and Elias K. Michaelis and Christian Sch{\"o}neich},
  journal={The Biochemical journal},
  year={2004},
  volume={383 Pt 2},
  pages={361-70}
}
The anti-apoptotic effect of Bcl-2 is well established, but the detailed mechanisms are unknown. In the present study, we show in vitro a direct interaction of Bcl-2 with the rat skeletal muscle SERCA (sarcoplasmic/endoplasmic reticulum Ca2+-ATPase), leading to destabilization and inactivation of the protein. Recombinant human Bcl-2D21, a truncated form of Bcl-2 with a deletion of 21 residues at the C-terminal membrane-anchoring region, was expressed and affinity-purified as a glutathione S… CONTINUE READING
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