Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript

@article{Gupta2006AntiapoptoticFO,
  title={Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript},
  author={Amita Gupta and Jared J. Gartner and Praveen Sethupathy and Artemis G. Hatzigeorgiou and Nigel W. Fraser},
  journal={Nature},
  year={2006},
  volume={442},
  pages={82-85}
}
MicroRNAs (miRNAs) are a class of small RNA molecules that regulate the stability or the translational efficiency of target messenger RNAs (mRNAs). The latency-associated transcript (LAT) of herpes simplex virus-1 (HSV-1) is the only viral gene expressed during latent infection in neurons. LAT inhibits apoptosis and maintains latency by promoting the survival of infected neurons. No protein product has been attributed to the LAT gene and the mechanism by which LAT protects cells from apoptosis… Expand
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