Anti-apoptotic effects of 3,5,3'-tri-iodothyronine in mouse hepatocytes.

  title={Anti-apoptotic effects of 3,5,3'-tri-iodothyronine in mouse hepatocytes.},
  author={Olga A Sukocheva and D. E. O. S. Carpenter},
  journal={The Journal of endocrinology},
  volume={191 2},
The present study demonstrates that 3,5,3'-tri-iodothyronine (T3) in physiological dose range inhibits tumor necrosis factor alpha(TNFalpha)/Fas-induced apoptosis in mouse hepatocytes. T3 pretreatment prevented Fas-induced early stage of apoptosis signs assessed by flow cytometry analysis of the annexin V positive cell population. T3 attenuated TNFalpha/Fas-induced cleavage of caspase-8 and DNA fragmentation. We found that T3 exerted its anti-apoptotic effects by mobilization of several non… CONTINUE READING
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