Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways.

  title={Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways.},
  author={Yoshihisa Ishikawa and Masanori Kitamura},
  journal={Kidney international},
  volume={58 3},
BACKGROUND Bioflavonoid quercetin inhibits hydrogen peroxide (H2O2)-induced apoptosis via intervention in the activator protein 1 (AP-1)-mediated apoptotic pathway. In this report, we investigated molecular events involved in the anti-apoptotic effect of quercetin, focusing especially on its effects on the family of mitogen-activated protein (MAP) kinases. METHODS Cultured mesangial cells were exposed to H2O2, and activation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated… 

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