Anti-apoptotic effect of microRNA-21 after contusion spinal cord injury in rats.

  title={Anti-apoptotic effect of microRNA-21 after contusion spinal cord injury in rats.},
  author={Jian-zhong Hu and Jiang-Hu Huang and Lei Zeng and Guan Wang and Min Cao and Hongbin Lu},
  journal={Journal of neurotrauma},
  volume={30 15},
Multiple cellular, molecular, and biochemical changes contribute to the etiology and treatment outcome of contusion spinal cord injury (SCI). Dysregulation of microRNAs (miRNAs) has been found following SCI in recent studies. However, little is known about the functional significance of the unique role of miRNAs in SCI. We analyzed the miRNA expression patterns 1 and 3 days following rat SCI using miRNA microarray. Microarray data revealed that nine miRNAs were upregulated and five miRNAs were… CONTINUE READING

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