Anti-apoptotic effect of insulin in the control of cell death and neurologic deficit after acute spinal cord injury in rats.

@article{Wu2007AntiapoptoticEO,
  title={Anti-apoptotic effect of insulin in the control of cell death and neurologic deficit after acute spinal cord injury in rats.},
  author={Xing-huo Wu and Shu-Hua Yang and De-yu Duan and Heng-hui Cheng and Yu-Ting Bao and Yukun Zhang},
  journal={Journal of neurotrauma},
  year={2007},
  volume={24 9},
  pages={
          1502-12
        }
}
Recent studies confirmed that the new cell survival signal pathway of Insulin-PI3K-Akt exerted cyto-protective actions involving anti-apoptosis. This study was undertaken to investigate the potential neuroprotective effects of insulin in the pathogenesis of spinal cord injury (SCI) and evaluate its therapeutic effects in adult rats. SCI was produced by extradural compression using modified Allen's stall with damage energy of 40 g-cm force. One group of rats was subjected to SCI in combination… CONTINUE READING

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