Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells.

  title={Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells.},
  author={Masashi Ikushima and Hiromi Rakugi and Kazuhiko Ishikawa and Yoshihiro Maekawa and Koichi Yamamoto and Junsuke Ohta and Yukana Chihara and Iwao Kida and Toshio Ogihara},
  journal={Biochemical and biophysical research communications},
  volume={339 3},
Klotho-mutated mice manifest multiple age-related disorders that are observed in humans. A recent study suggested that Klotho protein might function as an anti-aging hormone in mammals. Because it has been reported that apoptosis and senescence in vascular endothelial cells are closely related to the progression of atherosclerosis, we investigated Klotho's ability to interfere with apoptosis and cellular senescence in human umbilical vascular endothelial cells (HUVEC). Klotho overexpression… CONTINUE READING

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