Anti-angiogenic targets in the treatment of advanced renal cell carcinoma.

  title={Anti-angiogenic targets in the treatment of advanced renal cell carcinoma.},
  author={Daniel Yick Chin Heng and Ronald M. Bukowski},
  journal={Current cancer drug targets},
  volume={8 8},
Drugs that target the vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) pathways have revolutionized the treatment of patients with metastatic renal cell cancer (RCC). Patients with clear cell RCC often have mutations or silencing of the von Hippel Lindau gene leading to an accumulation of HIF 1 alpha. This allows growth factors such as VEGF and PDGF to be upregulated to promote angiogenesis and endothelial stabilization. Both sunitinib and sorafenib target… CONTINUE READING
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