Anti-angiogenic activities of snake venom CRISP isolated from Echis carinatus sochureki.

  title={Anti-angiogenic activities of snake venom CRISP isolated from Echis carinatus sochureki.},
  author={Shimon Lecht and Rachel A Chiaverelli and Jonathan A. Gerstenhaber and Juan J Calvete and Philip Lazarovici and Nicholas R. Casewell and Robert A. Harrison and Peter I. Lelkes and Cezary Marcinkiewicz},
  journal={Biochimica et biophysica acta},
  volume={1850 6},
BACKGROUND Cysteine-rich secretory protein (CRISP) is present in majority of vertebrate including human. The physiological role of this protein is not characterized. We report that a CRISP isolated from Echis carinatus sochureki venom (ES-CRISP) inhibits angiogenesis. METHODS The anti-angiogenic activity of purified ES-CRISP from snake venom was investigated in vitro using endothelial cells assays such as proliferation, migration and tube formation in Matrigel, as well as in vivo in quail… CONTINUE READING


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