Anti-angiogenic Therapy in Pediatric Neuro-oncology

  title={Anti-angiogenic Therapy in Pediatric Neuro-oncology},
  author={Mark W Kieran},
  journal={Journal of Neuro-Oncology},
In order to grow, tissues require additional nutrients and oxygen as well as removal of waste products. Tumors achieve this by up-regulating angiogenic cytokines and/or down-regulating natural inhibitory proteins that allow neovascularization to proceed. Brain tumors continue to account for significant morbidity and mortality, in spite of significant advances in neurosurgical and radiation techniques and new chemotherapy combinations. As such, there is a real and immediate need for novel… CONTINUE READING