Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells.

@article{Kawamura2003AntiangiogenesisEO,
  title={Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells.},
  author={Takanori Kawamura and Diana Z Liu and Murray J. Towle and Rena Kageyama and Naoko Tsukahara and Toshiaki Wakabayashi and B. Littlefield},
  journal={The Journal of antibiotics},
  year={2003},
  volume={56 8},
  pages={709-15}
}
Borrelidin, an antibiotic with anti-angiogenic activity, not only suppresses new capillary tube formation, but also collapses formed capillary tubes in a rat aorta culture model. Since it selectively inhibits threonyl-tRNA synthetase, we examined the effect of threonine on its anti-angiogenic activity. We found that a high concentration of threonine (1 mM) attenuated the ability of borrelidin to inhibit both capillary tube formation in the rat aorta culture model and human umbilical vein… CONTINUE READING

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