Anti-angiogenesis and angioprevention: mechanisms, problems and perspectives.

@article{Bisacchi2003AntiangiogenesisAA,
  title={Anti-angiogenesis and angioprevention: mechanisms, problems and perspectives.},
  author={Davide Bisacchi and Roberto Benelli and Christian Vanzetto and Nicoletta Ferrari and Francesca Tosetti and Adriana Albini},
  journal={Cancer detection and prevention},
  year={2003},
  volume={27 3},
  pages={229-38}
}
The recognition that angiogenesis is a key early event in tumor progression and metastasis has led to the development of new strategies for cancer therapy. The generation of a new blood vessel network under physiological conditions is regulated by the concerted action of activators and inhibitors. Perturbation of this balance, as it occurs in solid tumor growth and metastasis, appears to be a critical point in tumorigenesis. This has led to the "angiogenic switch" hypothesis: the point at which… CONTINUE READING

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