Anti-angiogenesis and RGD-containing snake venom disintegrins.

  title={Anti-angiogenesis and RGD-containing snake venom disintegrins.},
  author={Stephen D. Swenson and Swapnika Ramu and Francis S Markland},
  journal={Current pharmaceutical design},
  volume={13 28},
Angiogenesis is the fundamental process by which new blood vessels are formed. Extensive research has shown that this event can be co-opted by tumors to ensure their growth, survival and metastasis. The study of tumor angiogenesis therefore represents a promising area of research for development of anti-cancer therapeutics. Integrins, a family of cell surface molecules, are a major target of interest as they are known to play a vital role in pathological angiogenesis. Remarkably, small… 
Anti-angiogenic activities of two recombinant disintegrins derived from the Mohave and Prairie rattlesnakes.
Isolation of an Anti–tumour Disintegrin: Dabmaurin–1, a Peptide Lebein–1–like, from Daboia mauritanica Venom
Results show that if Dabmaurin–1 exhibits in vitro apparent anti–angiogenic effects at concentrations lower than 30 nM, it is likely because it acts as an anti–tumour disintegrin.
Recombinant and Chimeric Disintegrins in Preclinical Research
Recombinant disintegrins are obtained mainly through Escherichia coli, which is the most common host used for heterologous expression and the newest discoveries about this family of integrin-binding proteins are discussed.
[Potential use of snake venom components in cancer treatment].
The results of investigations, both in vitro and in vivo, which have shown promising results are revealed, thus revealing that the use of disintegrins could be a promising alternative for the treatment of different neoplasias.
Methods for Evaluation of a Snake Venom-Derived Disintegrin in Animal Models of Human Cancer.
A recombinant disintegrin, vicrostatin (VCN), that binds with high affinity and specificity to the Arg-Gly-Asp (RGD) class of integrins involved in tumor invasion and metastasis is engineered and evaluated in mouse models of human ovarian cancer, glioma, and prostate cancer.
Antitumoral Potential of Lansbermin-I, a Novel Disintegrin from Porthidium lansbergii lansbergii Venom on Breast Cancer Cells.
The results display the first report on the antitumor and anti-metastatic effects of an RGD-disintegrin isolated from a Porthidium snake venom by possibly interfering with α2 and/or β1-containing integrins and could be an attractive model for elucidating the role of disintegrins against breast cancer development.
Applications of snake venom components to modulate integrin activities in cell-matrix interactions.
  • C. Marcinkiewicz
  • Biology, Chemistry
    The international journal of biochemistry & cell biology
  • 2013