Anti-androgenic activities of Ganoderma lucidum.

  title={Anti-androgenic activities of Ganoderma lucidum.},
  author={Rumi Fujita and Jie Liu and Kuniyoshi Shimizu and Fumiko Konishi and Kiyoshi Noda and Shoichiro Kumamoto and Chie Ueda and Hisatoshi Tajiri and Shuhei Kaneko and Yoshitaro Suimi and Ryuichiro Kondo},
  journal={Journal of ethnopharmacology},
  volume={102 1},

Figures from this paper

Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum
Anti‐Androgen Effects of Extracts and Compounds from Ganoderma lucidum
Results showed that G. lucidum might be a useful ingredient in the treatment of androgen-induced diseases, such as benign prostatic hyperplasia or prostate cancer.
Ganoderic Acid TR, a New Lanostanoid with 5α-Reductase Inhibitory Activity from the Fruiting Body of Ganoderma Lucidum
By means of 5α-reductase inhibitory activity-guided fractionation, a new lanostanoid, 15α-hydroxy-3-oxolanosta- 7, 9(11), 24(E)-trien-26-oic acid, named as ganoderic acid TR, was isolated from the
Antiinflammatory lanostane triterpenoids from Ganoderma lucidum
All the compounds were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharides (LPS) in mouse macrophage RAW 264.7 cells in vitro.
Pharmacological Values of Medicinal Mushrooms for Prostate Cancer Therapy: The Case of Ganoderma Lucidum
To date, no effective therapy is available for clinically hormone-insensitive or hormone-refractory stages of prostate cancer.
Estrogen-like activity of ethanol extract of Ganoderma lucidum
The ethanol extract of G. lucidum showed estrogen-like activity, which may be useful in regulating hormone levels to treat related diseases such as osteoporosis if safety is fully guaranteed.
Screening of steroid 5-reductase inhibitory activity and total phenolic content of Thai plants
Steroid 5α-reductase is the enzyme responsible for changing androgen testosterone into the more potent androgen dihydrotestosterone (DHT). Overexpression of DHT can cause many disorders including
Diuretic Activity and Cytotoxic Study of Various Extracts of Ganoderma lucidum
In vivo study in BALC/c mice was conducted for the investigation of diuretic potential of Ganoderma lucidum and it concludes that methanolic extract has more diUREtic capability and not having any significant cytotoxicity.


The 5 alpha-reductase inhibitory components from heartwood of Artocarpus incisus: structure-activity investigations.
The methanol extract of heartwood of Artocarpus incisus showed potent 5 alpha-reductase inhibitory activity, and structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5alpha- reduct enzyme inhibitory effects.
Reishi, Ganoderma lucidum and Ganoderma tsugae: bioactive substances and medicinal effects
(1995). Reishi, Ganoderma lucidum and Ganoderma tsugae: Bioactive substances and medicinal effects. Food Reviews International: Vol. 11, Mushrooms: The Versatile Fungus-Food and Medicinal Properties,
Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective.
This review highlights some of the recently isolated and identified substances of higher Basidiomycetes mushrooms origin that express promising antitumor, immune modulating, cardiovascular and
Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3.
The data demonstrate that Ganoderma lucidum inhibits cell proliferation in a dose- and time-dependent manner by the down- regulation of expression of cyclin B and Cdc2 and by the up-regulation of p21 expression, and exerts its effect on cancer cells by multiple mechanisms.
Role of herbal compounds (PC-SPES) in hormone-refractory prostate cancer: two case reports.
PC-SPES has shown a strong estrogenic in vitro and in vivo activity as an alternative tool in the management of prostate cancer patients, suggesting that PC- SPES might have some potential activity against hormone-independent prostate cancers.
Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells.
Six new highly oxygenated lanostane-type triterpenes were isolated from the spores of Ganoderma lucidum, together with known ganolucidic acid D and ganoderic acid C2, and the cytotoxicity of the compounds was carried out in vitro against Meth-A and LLC tumor cell lines.
Differential expression of 5α‐reductase isoenzymes in the human prostate and prostatic carcinomas
Steroid 5α‐reductase is essential for the intracellular accumulation of dihydrotestosterone (DHT), which mediates androgen effects on target tissue.
Comparison of the effects of the 5 alpha-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies.
Results suggest that testosterone (T) can compensate for DHT to some degree at the level of the androgen receptor, despite increasingly higher doses of the antiandrogen flutamide.
A mushroom fruiting body-inducing substance inhibits activities of replicative DNA polymerases.
FIS is possibly a DNA polymerase inhibitor specific to the replicative enzyme group, and the fruiting body formation may be required for the suppression of the DNA replication or the vegetative growth of the mycelium.