Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in vitro: mechanism and possible structure-activity relationship investigation.

@article{Li2009AntiandrogenindependentPC,
  title={Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in vitro: mechanism and possible structure-activity relationship investigation.},
  author={Wei Li and Yong Hui Liu and Jiang-wei Zhang and Chun-Zhi Ai and Nan Xiang and Hui-Xin Liu and Ling Yang},
  journal={Archives of pharmacal research},
  year={2009},
  volume={32 1},
  pages={49-57}
}
Treatment of androgen-independent prostate cancer (AIPC) remains unsatisfactory. In our present experiment, natural occurring ginsenosides (NOGs) and intestinal bacterial metabolites (IBMs) were employed to investigate their anti-AIPC cell growth activity using PC-3 cells. Our results showed that the IBMs exerted more portent anti-AIPC activity than NOGs, by decreasing survival rate, inhibiting proliferation, inducing apoptosis, and leading to cell cycle arrest in AIPC PC-3 cells. The increase… CONTINUE READING