Anti- and proinflammatory cytokines in the pathogenesis of tissue damage in Crohn's disease.

@article{Hommes2000AntiAP,
  title={Anti- and proinflammatory cytokines in the pathogenesis of tissue damage in Crohn's disease.},
  author={Daniel W. Hommes and Sander J. van Deventer},
  journal={Current opinion in clinical nutrition and metabolic care},
  year={2000},
  volume={3 3},
  pages={191-5}
}
Crohn's disease is a chronic inflammatory bowel disease of unknown origin. The understanding of the pathogenesis of inflammatory bowel diseases has been greatly advanced by manipulations of the immune system in mice using targeted disruptions of genes that encode specific anti- and proinflammatory cytokines, as well as T-cell subsets. The outcome of these experiments has implicated CD4+ lymphocytes and certain proinflammatory cytokines (tumour necrosis factor-alpha, interleukin-12) as playing a… CONTINUE READING

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