Anti-analgesic and anti-amnesic effect of complement C3a.

  title={Anti-analgesic and anti-amnesic effect of complement C3a.},
  author={Yunden Jinsmaa and Masayuki Takahashi and Masaaki Yoshikawa},
  journal={Life sciences},
  volume={67 17},
In the present study, we found that complement C3a exerted central effects after intracerebroventricular administration in mice. At doses of 3 and 10 pmol/mouse, the peptide showed an antagonistic effect on analgesia induced by morphine and U-50488H, known to be mu- and kappa-opioid receptor agonists, respectively. Moreover, complement C3a improved scopolamine- and ischemia-induced amnesia at a dose of 10 pmol/mouse. Anti-analgesia was not observed by C3a des-Arg at 10 pmol/mouse. The present… CONTINUE READING