Anti-anaerobic activity of antibacterial agents.

  title={Anti-anaerobic activity of antibacterial agents.},
  author={Andr{\'e} Bryskier},
  journal={Expert opinion on investigational drugs},
  volume={10 2},
The first very effective bactericidal anti-anaerobic drug was metronidazole, introduced in clinical practice in the early 1980s. Sometimes penicillin G and chloramphenicol were used successfully in some anaerobic infections. However, this result was most likely due to Gram-positive anaerobic infections (e.g., Clostridium perfringens). Very rapidly, the anti-anaerobic armamentarium was extended with clindamycin, cefoxitin, imipenem and co-amoxyclav or piperacillin-tazobactam. The resistance rate… CONTINUE READING

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