Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils.

@article{Hirohata2012AntiamyloidogenicEO,
  title={Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils.},
  author={Mie Hirohata and Kenjiro Ono and Jun-ichi Takasaki and Ryoichi Takahashi and Tokuhei Ikeda and Akiyoshi Morinaga and Masahito Yamada},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1822 8},
  pages={1316-24}
}
Alzheimer's disease is characterized by the presence of extracellular deposits of amyloid, primarily composed of the amyloid β-protein (Aβ). A growing body of evidence indicates that oligomeric forms of Aβ play a critical role in disease causation. Soybean isoflavones are flavonoids with an isoflavone backbone. Isoflavones have been reported to protect against Aβ-induced neurotoxicity in cultured cell systems, the molecular mechanisms remain unclear. Our previous studies demonstrated that red… CONTINUE READING
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