Anti-aminoacyl tRNA synthetase immune responses: insights into the pathogenesis of the idiopathic inflammatory myopathies.

@article{Levine2003AntiaminoacylTS,
  title={Anti-aminoacyl tRNA synthetase immune responses: insights into the pathogenesis of the idiopathic inflammatory myopathies.},
  author={Stuart M. Levine and Antony Rosen and Livia A. Casciola-Rosen},
  journal={Current opinion in rheumatology},
  year={2003},
  volume={15 6},
  pages={708-13}
}
PURPOSE OF REVIEW One of the most striking humoral characteristics of the idiopathic inflammatory myopathies is the specific targeting of components of the translational machinery by the immune system. The most commonly targeted of these components are the aminoacyl tRNA synthetase (ARS) molecules. However, the relation between the immune responses to these molecules and the pathogenesis of the inflammatory myopathies remains obscure. This review will examine recent evidence that explores the… CONTINUE READING

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