Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia.

@article{Ragle2009AntialphahemolysinMA,
  title={Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia.},
  author={Brook E Ragle and Juliane Bubeck Wardenburg},
  journal={Infection and immunity},
  year={2009},
  volume={77 7},
  pages={2712-8}
}
Staphylococcus aureus pneumonia is one of the most common invasive diseases caused by this human pathogen. S. aureus alpha-hemolysin, a pore-forming cytotoxin, is an essential virulence factor in the pathogenesis of pneumonia. Vaccine-based targeting of this toxin provides protection against lethal staphylococcal pneumonia in a murine model system, suggesting that a monoclonal antibody-based therapy may likewise prove to be efficacious for prevention and treatment of this disease. We report the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 76 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Similar Papers

Loading similar papers…