Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function.

@article{Kim2016AntiagingTS,
  title={Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function.},
  author={Dong Kyu Kim and Hee-Sun Lim and Ichiro Kawasaki and Yhong-Hee Shim and Nishant N. Vaikath and Omar M. A. El-Agnaf and Hsinyu Lee and Seung-Jae Lee},
  journal={Autophagy},
  year={2016},
  volume={12 10},
  pages={
          1849-1863
        }
}
Aging is the major risk factor for neurodegenerative diseases that are also associated with impaired proteostasis, resulting in abnormal accumulation of protein aggregates. However, the role of aging in development and progression of disease remains elusive. Here, we used Caenorhabditis elegans models to show that aging-promoting genetic variations accelerated the rate of cell-to-cell transmission of SNCA/α-synuclein aggregates, hallmarks of Parkinson disease, and the progression of disease… CONTINUE READING
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