Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway.

@article{Tajes2009AntiagingPO,
  title={Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway.},
  author={Marta Tajes and Javier Guti{\'e}rrez-Cuesta and Daniel Ortu{\~n}o-Sahag{\'u}n and Antoni Camins and Merc{\`e} Pall{\`a}s},
  journal={Journal of pineal research},
  year={2009},
  volume={47 3},
  pages={228-37}
}
Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted considerable attention as mediators of lifespan extension in several model organisms. Induction of sirtuin 1 expression also attenuates neuronal degeneration and death in animal models of Alzheimer's disease and Huntington's disease. In this study, an in vitro model of neuronal aging was used to test in several ways whether melatonin acts as a sirtuin 1 inducer and if this effect could be neuroprotective… CONTINUE READING
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