Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.

@article{Ishikawa2008AntiadultTL,
  title={Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.},
  author={C. Millikin Ishikawa and Senji Tafuku and Takashi Kadekaru and Shigeki Sawada and Mariko Tomita and Taeko Okudaira and Tetsuro Nakazato and Takayoshi Toda and Jun-nosuke Uchihara and Naoya Taira and Kazuiku Ohshiro and Takeshi Yasumoto and Takao Ohta and Naoki Mori},
  journal={International journal of cancer},
  year={2008},
  volume={123 11},
  pages={2702-12}
}
Adult T-cell leukemia (ATL) is a fatal malignancy of T lymphocytes caused by human T-cell leukemia virus type 1 (HTLV-1) infection and remains incurable. Carotenoids are a family of natural pigments and have several biological functions. Among carotenoids, fucoxanthin is known to have antitumorigenic activity, but the precise mechanism of action is not elucidated. We evaluated the anti-ATL effects of fucoxanthin and its metabolite, fucoxanthinol. Both carotenoids inhibited cell viability of… CONTINUE READING
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