Anti-adrenergic effects of angiotensin converting enzyme inhibitors.

  title={Anti-adrenergic effects of angiotensin converting enzyme inhibitors.},
  author={Michael R. Bristow and William T. Abraham},
  journal={European heart journal},
  volume={16 Suppl K},
The renin-angiotensin and adrenergic nervous systems are cross-regulated compensatory mechanisms that are induced or activated in the failing heart. In ventricular myocardium, the activation of one of these systems leads to activation or induction of the other, resulting in co-amplification of cellular mechanisms that result in cardiac myocyte hypertrophy, hyperplasia of nonmyocytic tissue components, increased contractility and heart rate, and increased ventricular volume. Although these… CONTINUE READING


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