Anti-adenovirus humoral responses influence on the efficacy of vaccines based on epitope display on adenovirus capsid.

@article{Lanzi2011AntiadenovirusHR,
  title={Anti-adenovirus humoral responses influence on the efficacy of vaccines based on epitope display on adenovirus capsid.},
  author={Anastasia Lanzi and Ghada Ben Youssef and M. Perricaudet and Karim Benihoud},
  journal={Vaccine},
  year={2011},
  volume={29 7},
  pages={1463-71}
}
The efficacy of recombinant adenoviruses (Ads) vaccine vectors is diminished by the high prevalence of anti-Ad antibodies (Abs) that hampers gene transfer. Epitope display on Ad capsid constitutes an alternative approach to bypass anti-Ad Ab capacity from blocking antigen expression. To understand the role of the epitope insertion site, an ovalbumin-derived epitope was genetically inserted into either Ad hexon or fiber proteins. Hexon-modified Ads triggered higher anti-ovalbumin Ab responses… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…