Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatment

@article{Maisonneuve2003AntiaddictiveAO,
  title={Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatment},
  author={Isabelle M. Maisonneuve and Stanley D. Glick},
  journal={Pharmacology Biochemistry and Behavior},
  year={2003},
  volume={75},
  pages={607-618}
}
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104 Citations
Highly Influential Citations
8
Background Citations
47
Methods Citations
1
Results Citations
2

104 Citations

Citation Type

Citation Type

Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration.
18-Methoxycoronaridine: a potential new treatment for obesity in rats?
TLDR
Data suggest that antagonism of α3β4 nicotinic receptors may be involved in the regulation of intake of palatable substances regardless of its caloric value and may participate in maintaining obesity.
Effect of Iboga Alkaloids on µ-Opioid Receptor-Coupled G Protein Activation
TLDR
Evidence regarding the activation of μ-opioid receptor (MOR)-related G proteins by iboga alkaloids is replicated and extended to suggest a novel mechanism of action, and further justify the search for alternative targets of ibogamine skeleton compounds.
Attenuation of morphine withdrawal signs by intracerebral administration of 18-methoxycoronaridine.
Brain regions mediating α3β4 nicotinic antagonist effects of 18- MC on methamphetamine and sucrose self-administration
TLDR
Results are consistent with the hypothesis that 18-MC decreases methamphetamine self-administration by indirectly modulating the dopaminergic mesolimbic pathway via blockade of α3β4 nicotinic receptors in the habenulo-interpeduncular pathway and the basolateral amygdala.
18-Methoxycoronaridine, a potential anti-obesity agent, does not produce a conditioned taste aversion in rats
Brain regions mediating α3β4 nicotinic antagonist effects of 18-MC on nicotine self-administration.
Brain regions mediating alpha3beta4 nicotinic antagonist effects of 18-MC on methamphetamine and sucrose self-administration.
Behavioural Pharmacology of Novel Kappa Opioid Compounds
TLDR
This study provides evidence to suggest the involvement of the serotonin system in Sal A and DS1 induced depression and a difference in modulation of serotonin transporter function by novel and traditional KOPr agonists was observed.
Novel pharmacotherapeutic treatments for cocaine addiction
TLDR
The most recent human clinical trials of potential medications for treatment of cocaine dependence are discussed as well as pre-clinical studies for another promising agent, levo tetrahydropalmatine, whose mechanism remains to be determined.
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References

SHOWING 1-10 OF 103 REFERENCES
18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats
The potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatment
Development of Novel Medications for Drug Addiction: The Legacy of an African Shrub
TLDR
All of the data indicate that 18‐MC should be safer than ibogaine and at least as efficacious as an anti‐addictive medication.
Modulation of nicotine self-administration in rats by combination therapy with agents blocking α3β4 nicotinic receptors
Interactions between ibogaine, a potential anti-addictive agent, and morphine: an in vivo microdialysis study.
Interactions between 18-methoxycoronaridine (18-MC) and cocaine: dissociation of behavioural and neurochemical sensitization
18‐MC reduces methamphetamine and nicotine self‐administration in rats
TLDR
It is suggested that a nicotinic antagonist action of 18-MC contributes to its putative anti-addictive efficacy and is least effective in decreasing methamphetamine self-administration and most potent in decreasing nicotine self-Administration.
Attenuation of Alcohol Consumption by a Novel Nontoxic Ibogaine Analogue (18-Methoxycoronaridine) in Alcohol-Preferring Rats
Attenuation of the reinforcing efficacy of morphine by 18-methoxycoronaridine.
Acute iboga alkaloid effects on extracellular serotonin (5-HT) levels in nucleus accumbens and striatum in rats
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