Anti-West Nile virus activity of in vitro expanded human primary natural killer cells

@inproceedings{Zhang2009AntiWestNV,
  title={Anti-West Nile virus activity of in vitro expanded human primary natural killer cells},
  author={Mingjie Zhang and Sylvester Daniel and Yong Huang and Caren Chancey and Qingsheng Huang and Ying F Lei and Andriyan Grinev and Howard S. Mostowski and Mar{\'i}a R{\'i}os and Andrew I. Dayton},
  booktitle={BMC Immunology},
  year={2009}
}
Natural Killer (NK) cells are a crucial component of the host innate immune system with anti-viral and anti-cancer properties. However, the role of NK cells in West Nile virus (WNV) infection is controversial, with reported effects ranging from active suppression of virus to no effect at all. It was previously shown that K562-mb15-41BBL (K562D2) cells, which express IL-15 and 4-1BBL on the K562 cell surface, were able to expand and activate human primary NK cells of normal peripheral blood… CONTINUE READING
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