Anti-VEGF therapy for crescentic glomerulonephritis?


rom 0.7 to 4.8 mg/dL (62-424 mol/L), but there was no vidence of nonlinearity in the calibration (r-square of 0.9994 n Fig 3 of with slopes of 0.900 and 0.907 for values below nd above 2.0 mg/dL [177 mol/L], respectively; P value or the interaction, 0.5). The points near 1 mg/dL (88.4 mol/L) appear closer to the line of identity but not more so han one would expect with a 0 intercept and constant slope f 0.9, which implies a distance of 0.1 mg/dL at 1.0 mg/dL nd 0.2 mg/dL at 2.0 mg/dL. Therefore, application of the alibration to a more limited range of serum creatinine alues is appropriate. In contrast, our NHANES paper finds different slope in the association between a kinetic rate affé assay and the Roche enzymatic assay. However, it hould be noted that across the NHANES datasets, the lopes (standard error) showed substantial variation, at 0.939 0.015), 0.997 (0.012), 1.010 (0.013), and 0.976 (0.013) Table 1 of). Thus, re-expression of the MDRD Study quation was based on data specifically comparing the DRD Study creatinine results to an assay traceable to old-standard methods, with all assays done in the Cleveand Clinic Research Laboratory. We do not think it would e helpful to combine data from other laboratories in rexpressing the MDRD Study equation. The MDRD Study quation is less useful with low serum creatinine values ecause at high values of estimated GFR, the formula nderestimates measured GFR. Josef Coresh, MD, PhD Elizabeth Selvin, PhD Lesley A. Stevens, MD, MS Andrew S. Levey, MD Fredrick Van Lente, PhD Johns Hopkins Medical Institutions Baltimore, Maryland Tufts-New England Medical Center Boston, Massachusetts Cleveland Clinic Foundation Cleveland, Ohio

DOI: 10.1053/j.ajkd.2007.12.042

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Cite this paper

@article{Kitamoto2008AntiVEGFTF, title={Anti-VEGF therapy for crescentic glomerulonephritis?}, author={Yasunori Kitamoto and Y. Yoshio Taguma and Kenji Arizono and Takahisa Imamura}, journal={American journal of kidney diseases : the official journal of the National Kidney Foundation}, year={2008}, volume={51 4}, pages={710-1} }