Anti-VEGF aptamer (pegaptanib) therapy for ocular vascular diseases.

  title={Anti-VEGF aptamer (pegaptanib) therapy for ocular vascular diseases.},
  author={Eugene W. M. Ng and Anthony P. Adamis},
  journal={Annals of the New York Academy of Sciences},
Vascular endothelial growth factor (VEGF) is a central regulator of both physiological and pathological angiogenesis. Pegaptanib, a 28-nucleotide RNA aptamer specific for the VEGF(165) isoform, binds to it in the extracellular space, leaving other isoforms unaffected, and inhibits such key VEGF actions as promotion of endothelial cell proliferation and survival, and vascular permeability. Pegaptanib already has been examined as a treatment for two diseases associated with ocular… CONTINUE READING


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