Anti-VEGF Therapy in Cancer : A Double-Edged Sword

  title={Anti-VEGF Therapy in Cancer : A Double-Edged Sword},
  author={Victor Gardner and Chikezie O. Madu and Yi Lu},
Vascular endothelial growth factor (VEGF) is a mitogen that plays a crucial role in angiogenesis and lymphangiogenesis. It is involved in tumor survival through inducing tumor angiogenesis and by increasing chemoresistance through autocrine signaling. Because of its importance in tumor formation and survival, several medications have been developed to inhibit VEGF and reduce blood vessel formation in cancer. Although these medications have proven to be effective for late-stage and metastatic… CONTINUE READING


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