Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases

@article{Webster1996AntiTumorAI,
  title={Anti-Tumor Activity, In Vitro and In Vivo, of Some
Triphenylphosphinegold(I) Thionucleobases},
  author={Lorraine K. Webster and Silvina Rainone and Ernst Horn and Edward R T Tiekink},
  journal={Metal-Based Drugs},
  year={1996},
  volume={3},
  pages={63 - 66}
}
The [Ph(3)PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [Ph(3)PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both [Ph(3)PAu(6-MP… CONTINUE READING