Anti-Tuberculous Activity of Treponemycin Produced by a Streptomyces Strain MS-6-6 Isolated from Saudi Arabia

@article{Yassien2015AntiTuberculousAO,
  title={Anti-Tuberculous Activity of Treponemycin Produced by a Streptomyces Strain MS-6-6 Isolated from Saudi Arabia},
  author={Mahmoud. A. Yassien and Hossam Mohamed Abdallah and Ali M. El-Halawany and Asif Ahmad Jiman-Fatani},
  journal={Molecules},
  year={2015},
  volume={20},
  pages={2576 - 2590}
}
A Streptomyces strain MS-6-6 with promising anti-tuberculous activity was isolated from soil samples in Saudi Arabia. The nucleotide sequence of its 16S rRNA gene (1426 bp) evidenced a 100% similarity to Streptomyces mutabilis. Through an anti-tuberculous activity-guided approach, a polyketide macrolide was isolated and identified as treponemycin (TP). The structure of the isolated compound was determined by comprehensive analyses of its 1D and 2D NMR as well as HRESI-MS. In addition to the… 

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References

SHOWING 1-10 OF 42 REFERENCES
Isolation of borrelidin from Streptomyces californicus—An Indian soil isolate
TLDR
The active compound was identified as borrelidin, being reported as new compound from S. californicus, which has both antibacterial and antifungal activity and was found to inhibit the neoangiogenesis in fertile eggs.
Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
In this study, an endophytic Streptomyces sp. neau-D50 with strong antifungal activity against Phytophthora sojae was isolated from healthy soybean root, using an in vitro screening technique. A
Streptomyces heilongjiangensis sp. nov., a novel actinomycete that produces borrelidin isolated from the root surface of soybean [Glycine max (L.) Merr].
TLDR
It is proposed that strain NEAU-W2(T) represents a novel StrePTomyces species, Streptomyces heilongjiangensis sp.
Antifungal Macrodiode Production By Streptomyces albidoflavus-143: Fermentation, Purification and Biological Activities
TLDR
The purified antifungal agent was suggestive of being belonging to Macrodiode antibiotic produced by Streptomyces albidoflavus, 143, and had a suggested imperical formula of C 22 H 36 O 6.
PRODUCTION OF ANTITUMOR ANTIBIOTIC BY STREPTOMYCES CAPOAMUS
TLDR
Optimum temperature, pH and incubation period for the production of antitumor antibiotic were found to be 30 o C, 7.5 and 72 hrs, respectively, and 2% maltose as carbon source, 2% corn steep liquor as nitrogen source and 48 hrs old inoculum at a concentration of 8% (v/v) were finding to be the best for antitumors antibiotic production by Streptomyces capoamus NRRL B3632.
Isolation of Borrelidin as a Phytotoxic Compound from a Potato Pathogenic Streptomyces Strain
TLDR
This is the first report on the phytotoxicity of borrelidin as a possible causative compound of potato scab disease.
Antimicrobial and cytotoxic activity of Streptomyces sp. from Lonar Lake.
TLDR
Metabolites in the extract of broth of 48 hrgrown Streptomyces spp.
Influence of Culture Conditions on Pectinase Production by Streptomyces sp. (Strain J9)
TLDR
Enzyme production and activity were strongly decreased at 45°C and acidic pH, and inhibited when Streptomyces strain (J2) was grown in CMC broth supplemented with arabinose and yeast extract as a sole carbon and nitrogen source.
Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent d-Cycloserine Produced by Streptomyces lavendulae
TLDR
A 21-kb DNA fragment containing a d-cycloserine (DCS) biosynthetic gene cluster from a DCS-producing Streptomyceslavendulae strain, ATCC 11924, is cloned and it is revealed that the introduced genes are responsible for the biosynthesis of DCS.
Susceptibility Testing of Extensively Drug-Resistant and Pre-Extensively Drug-Resistant Mycobacterium tuberculosis against Levofloxacin, Linezolid, and Amoxicillin-Clavulanate
TLDR
The results demonstrate that LZD may be effective for the treatment of XDR and pre-XDR cases from Pakistan, and high resistance rates against LVX in this study suggest the use of this drug with caution for DR-TB cases from this area.
...
...