Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis.

@article{Desplatjgo2005AntiTWEAKMA,
  title={Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis.},
  author={Sophie Desplat-j{\'e}go and Rita Creidy and Simone Varriale and Normand Edouard Allaire and Yi Luo and Dominique Bernard and Kyungmin Hahm and Linda Burkly and Jos{\'e} Boucraut},
  journal={Clinical immunology},
  year={2005},
  volume={117 1},
  pages={
          15-23
        }
}
TWEAK is a member of the TNF family, constitutively expressed in the central nervous system (CNS), with pro-inflammatory, proliferative or apoptotic effects depending upon cell types. Its receptor, Fn14, is expressed in CNS by endothelial cells, reactive astrocytes and neurons. We showed that TWEAK and Fn14 mRNA expression increased in spinal cord during experimental autoimmune encephalomyelitis (EAE). We investigated the role of TWEAK during EAE using neutralizing anti-TWEAK antibody in myelin… CONTINUE READING
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