Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy.

@article{Sommer2001AntiTNFneutralizingAR,
  title={Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy.},
  author={Claudia L Sommer and Thies Lindenlaub and P Teuteberg and Maria Sch{\"a}fers and Thomas Hartung and Klaus Victor Toyka},
  journal={Brain research},
  year={2001},
  volume={913 1},
  pages={86-9}
}
We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-alpha (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced… CONTINUE READING