Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion

@inproceedings{Cavallaro2017AntiTNFMediatedMO,
  title={Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion},
  author={Flaminia Cavallaro and L. de J.A.D. Duca and Laura Francesca Pisani and Francesca Carrara and L. A. R. Spina and Gian Eugenio Tontini and Nadia Munizio and Elena Costa and Maria Domenica Cappellini and Maurizio Vecchi and Luca Pastorelli},
  booktitle={Canadian journal of gastroenterology & hepatology},
  year={2017}
}
Background. Anaemia is common in inflammatory bowel disease (IBD), frequently resulting from a combination of iron deficiency and of anaemia of chronic disease (ACD). ACD is characterized by macrophage iron retention induced by proinflammatory cytokines. Hepcidin is the master inducer of iron accumulation during ACD, and its production is mainly regulated by IL-6 and the novel erythroid hormone erythroferrone (ERFE). This study evaluates whether anti-TNF monoclonal antibodies therapy modurates… CONTINUE READING

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