Anti-TNF-α therapies: the next generation

@article{Palladino2003AntiTNFTT,
  title={Anti-TNF-α therapies: the next generation},
  author={M. Palladino and F. R. Bahjat and E. Theodorakis and L. Moldawer},
  journal={Nature Reviews Drug Discovery},
  year={2003},
  volume={2},
  pages={736-746}
}
The functioning of the immune system is finely balanced by the activities of pro-inflammatory and anti-inflammatory mediators or cytokines. Unregulated activities of these mediators can lead to the development of serious inflammatory diseases. In particular, enhanced tumour-necrosis factor-α (TNF-α) synthesis is associated with the development of rheumatoid arthritis, psoriatic arthritis and inflammatory bowel disease. Inhibiting TNF-α activities in these diseases has been remarkably successful… Expand
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  • 15
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  • 11
  • Highly Influenced
  • PDF
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  • 55
  • PDF
Current perspective of TACE inhibitors: a review.
  • 109
Drug discovery and development for inflammatory diseases.
  • C. Edwards
  • Medicine
  • Expert opinion on therapeutic targets
  • 2004
  • 11
Small-molecule inhibitors of the interaction between TNF and TNFR.
  • 19
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 125 REFERENCES
Anti-TNFalpha therapy for rheumatoid arthritis: an update.
  • 83
Uncoupling of inflammatory and destructive mechanisms in arthritis.
  • 75
Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.
  • 779
  • PDF
Tumour necrosis factor in synovial exudates.
  • 210
  • PDF
...
1
2
3
4
5
...