Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors.

Abstract

Strategies to activate and rescue exhausted tumor-specific T cells, including the use of monoclonal antibodies (mAb) that block the negative costimulatory receptors CTLA-4 and PD-1 are proving very effective, but TIM3 has been relatively neglected as a target. Here we report an extensive characterization of the therapeutic activity and mechanism of action… (More)
DOI: 10.1158/0008-5472.CAN-11-0096

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@article{Ngiow2011AntiTIM3AP, title={Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors.}, author={Shin Foong Ngiow and Bianca von Scheidt and Hisaya Akiba and Hideo Yagita and Michele W. L. Teng and Mark J Smyth}, journal={Cancer research}, year={2011}, volume={71 10}, pages={3540-51} }