Anti-TAR polyamide nucleotide analog conjugated with a membrane-permeating peptide inhibits human immunodeficiency virus type 1 production.

@article{Kaushik2002AntiTARPN,
  title={Anti-TAR polyamide nucleotide analog conjugated with a membrane-permeating peptide inhibits human immunodeficiency virus type 1 production.},
  author={Neerja Kaushik and Amartya Basu and Paul Palumbo and Rene L. Myers and Virendra N Pandey},
  journal={Journal of virology},
  year={2002},
  volume={76 8},
  pages={3881-91}
}
The emergence of drug-resistant variants has posed a significant setback against effective antiviral treatment for human immunodeficiency virus (HIV) infections. The choice of a nonmutable region of the viral genome such as the conserved transactivation response element (TAR element) in the 5' long terminal repeat (LTR) may potentially be an effective target for drug development. We have earlier demonstrated that a polyamide nucleotide analog (PNA) targeted to the TAR hairpin element, when… CONTINUE READING