Anti-T12, an anti-CD6 monoclonal antibody, can activate human T lymphocytes.

  title={Anti-T12, an anti-CD6 monoclonal antibody, can activate human T lymphocytes.},
  author={R M Gangemi and J A Swack and D M Gaviria and Paul L. Romain},
  journal={Journal of immunology},
  volume={143 8},
Anti-T12 is a murine IgM mAb that recognizes the 130-kDa CD6 glycoprotein on mature human T lymphocytes. Examination of the in vitro effects of this mAb on freshly isolated T cells demonstrates that anti-T12 can induce T cell activation. Such activation is macrophage-dependent, and optimal stimulation occurs with 0.2 to 5 micrograms/ml of purified mAb. This response to soluble mAb is detectable at day 4 to 5 of culture, and peak [3H]TdR uptake is observed at day 7. In a highly similar fashion… CONTINUE READING
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