Anti-Sm and anti-RNP antibodies

@article{Migliorini2005AntiSmAA,
  title={Anti-Sm and anti-RNP antibodies},
  author={Paola Migliorini and Chiara Baldini and Valeria Rocchi and Stefano Bombardieri},
  journal={Autoimmunity},
  year={2005},
  volume={38},
  pages={47 - 54}
}
Among anti-nuclear antibodies, anti-Sm and anti-RNP antibodies are of the utmost importance in clinical practice. Anti-Sm antibodies are directed against 7 proteins (B/B′, D1, D2, D3, E, F, G) that constitute the common core of U1, U2, U4 and U5 small nuclear ribonucleoprotein (snRNP) particles; B/B′, D1 and D3 are more frequently targeted. Anti-RNP antibodies react with proteins (70 Kd, A, C) that are associated with U1 RNA and form U1snRNP. Anti-Sm and anti-RNP antibodies are directed towards… 
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230 Citations
Highly Influential Citations
10
Background Citations
72
Methods Citations
4
Results Citations
8

230 Citations

Anti-Sm and Anti-U1-RNP Antibodies: An Update
TLDR
The recent development of novel assays and the characterization of the target epitopes have been beneficial to improve the sensitivity for anti-Sm/U1-RNP Ab detection, but the necessity to use a different assay remains mandatory.
Significance of anti-ribonucleoprotein (RNP) antibody and anti-Smith (anti-Sm) antibody among patients with SLE or MCTD
TLDR
Among patients showing positivity for anti-RNP antibody alone, those with MCTD seem likely to develop pure MN, while those with SLE tend to have MES as well as MN.
Altered posttranslational modification on U1 small nuclear ribonucleoprotein 68k in systemic autoimmune diseases detected by 2D Western blot
TLDR
This U1‐68k isoform, in particular, in its RS domain, was found to have significantly decreased phosphorylation compared to the other isoforms, suggesting that the PTM alternation may be one of the steps to generate the anti‐RNP antibodies.
Proteomic analyses and identification of arginine methylated proteins differentially recognized by autosera from anti-Sm positive SLE patients
TLDR
This study showed that hnRNP DL and CNBP are novel antigens for SLE patients and the recognition of CNBP might be differentiated dependent on the level of arginine methylation.
Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study
TLDR
Results indicate that serum anti-U1-70k antibodies are associated with psychiatric syndromes in SLE but that they are not associated with CNS Syndromes as a whole or with neurologic syndrome.
The diagnostic challenge of patients with anti-U1-RNP antibodies
TLDR
The presence of scleroderma features, including swollen hands, sclerodactyly, gastro-oesophageal reflux, and the absence of those manifestations suggested the diagnosis of another definite connective tissue disease, especially SLE, while patients meeting the MCTD criteria were more likely to display SSc features.
The Predictive Value of Autoantibody Spectrum on Organ Damage in Patients With Systemic Lupus Erythematosus.
TLDR
There are differences in the autoantibodies distribution of SLE patients with different organ damage, suggesting a certain clinical value for prediction of organ damage in SLE.
Early targets of nuclear RNP humoral autoimmunity in human systemic lupus erythematosus.
TLDR
The similarity and cross-reactivity between the initial targets of nRNP and Sm autoantibodies identifies a likely commonality in cause and a focal point for intermolecular epitope spreading.
Negative correlation of anti-U1RNP antibody titers and the amount of salivary secretion with age correction.
TLDR
The presence of anti-U1RNP antibodies is associated with reduced ASS, and the pathological findings of minor salivary gland biopsy in 2 subjects were compatible with Sjögren's syndrome; one subject showed moderate lymphocytic infiltration.
Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus
TLDR
It is concluded that the reported difference in the sensitivity is related to the different cut-off levels and not to the detection of anti-dsDNA antibodies bridged via dsDNA to the SmD1 peptide.
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