Anti-Self Phosphatidylserine Antibodies Recognize Uninfected Erythrocytes Promoting Malarial Anemia.

@article{FernndezArias2016AntiSelfPA,
  title={Anti-Self Phosphatidylserine Antibodies Recognize Uninfected Erythrocytes Promoting Malarial Anemia.},
  author={Cristina Fern{\'a}ndez-Arias and Juan Rivera-Correa and Julio Gallego-Delgado and Rachel M. Rudlaff and Clemente Fernandez and Camille Roussel and Anton G{\"o}tz and Sandra P. Gonzalez and Akshaya Kumar Mohanty and Sanjib P Mohanty and Samuel C Wassmer and Pierre A Buffet and Papa Alioune Ndour and Ana Rodr{\'i}guez},
  journal={Cell host & microbe},
  year={2016},
  volume={19 2},
  pages={194-203}
}
Plasmodium species, the parasitic agents of malaria, invade erythrocytes to reproduce, resulting in erythrocyte loss. However, a greater loss is caused by the elimination of uninfected erythrocytes, sometimes long after infection has been cleared. Using a mouse model, we found that Plasmodium infection induces the generation of anti-self antibodies that bind to the surface of uninfected erythrocytes from infected, but not uninfected, mice. These antibodies recognize phosphatidylserine, which is… CONTINUE READING