Anti-Scarring Properties of Different Tryptophan Derivatives

  title={Anti-Scarring Properties of Different Tryptophan Derivatives},
  author={Malihe-Sadat Poormasjedi-Meibod and Ryan V Hartwell and Ruhangiz Taghi Kilani and Aziz Ghahary},
  booktitle={PloS one},
Hypertrophic scars are associated with prolonged extracellular matrix (ECM) production, aberrant ECM degradation and high tissue cellularity. Routinely used antifibrotic strategies aim to reduce ECM deposition and enhance matrix remodeling. Our previous study investigating the antifibrotic effects of indoleamine2, 3 dioxygenase (IDO) led to the identification of kynurenine (Kyn) as an antiscarring agent. A topical antifibrogenic therapy using Kyn is very attractive; however, it is well… CONTINUE READING